Diluting Lyse Agent

Diluents are low-molecular-weight, low-viscosity compounds that are used to reduce the viscosity or enhance the solubility of a resin and/or hardener.

Diluents are low-molecular-weight, low-viscosity compounds that are used to reduce the viscosity or enhance the solubility of a resin and/or hardener. Diluents may be either reactive or non-reactive. However, the reactive types are more desirable since they combine chemically with the main resin during cure and are not free to outgas or leach, especially during thermal-vacuum exposure. Epoxy diluents, for example, are formulated together with epoxy resins to reduce the viscosity and still remain 100% solids. Normally, solvents would be used to reduce viscosity, but most organic solvents are now being disallowed because of their high volatile emissions. Some long-chain aliphatic reactive diluents can also improve the flexural strength of epoxy adhesives.

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Our diluent is a factor that is often overlooked, but which may deserve attention at the stage of method optimization. If the diluent has a stronger eluting strength than the MP, sample peaks (especially early-eluting peaks) may be severely distorted because of solvent mismatch, which may cause problems in impurity determinations. Such a situation is often encountered in both RP and NP when a sample has limited solubility in diluents with composition close to the MP. Higher content of polar organic solvent is often added to diluent to achieve adequate sample concentration. To prevent this distortion from happening, The solutions to increase the analyte's solubility in diluent with low polarity should be considered, depending on the analyte's physicochemical properties.

Diluting Lyse Agent

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